GSR may refer to:
Law
- General Statutory Rules
Medicine, science and technology
- Galvanic skin response, physiological phenomenon
- Glutathione-disulfide reductase, enzyme
- Gunshot residue
Organizations
- Gas Safe Register, in the United Kingdom
- Global Sea Mineral Resources, an underwater mining company
- Groupe Scolaire La Résidence, a French international school in Casablanca, Morocco
Places
- Gerber Scout Reservation, a scouting facility in Michigan, U.S.
- Postal code for Għasri, Gozo Island, Malta
- Grand Sierra Resort, a hotel and casino in Nevada, U.S.
Transport
- Acura Integra GS-R, an automobile
- IATA code for Qardho Airport, Somalia
Rail systems
- Great Southern Railway (disambiguation)
- Great Southern Railways, a former Irish railway company
- Gondal State Railway, in British India
- Great Sandhills Railway, a Canadian railway
Other uses
- Greenville Swamp Rabbits
- Grammata Serica Recensa, a dictionary of Old Chinese
- General Service Respirator, a military gas mask
- SIG Sauer GSR, a pistol variety