GPF may refer to:
Military
- Canon de 155mm GPF, a French heavy artillery gun
- General Purpose Frigate (Canada)
- Gozarto Protection Force, a Syrian militia
Organizations
- Global Peace Foundation
- Global Philanthropy Forum
- Global Policy Forum, an American international government accountability organization
Sports
- Global Pickleball Federation
- Grand Prix of Figure Skating Final
Other
- Gallons per flush*, a measure of flush toilet water efficiency
- General protection fault, a computer error on the Intel x86 architecture
- Greater palatine foramen
- Grosse Pointe Farms
- Yaroslavl Global Policy Forum, an international forum