Frank Grimes (1947–2025) was an Irish actor.
Frank Grimes may also refer to:
- Frank Grimes, a character in The Simpsons
- Frank Grimes, Jr., son of Frank Grimes, in The Simpsons episode "The Great Louse Detective"
- Lt. Frank Grimes, character in the 2002 movie John Q
- Francis "Frank" Grimes, character in the show Ugly Americans