Francisco Herrera may refer to:
- Francisco Herrera the Elder (1576–1656), Spanish painter
- Francisco Herrera the Younger (1622–1685), his son, Spanish painter
- Francisco Herrera Jiménez (born 1965), Mexican politician
- Francisco Herrera Latoja (), Chilean military officer and public official
- Francisco Herrera León (born 1966), Mexican politician
- Francisco Herrera Luque (1927–1991), Venezuelan writer
- Francisco Herrera (baseball), Los Angeles Dodgers clubhouse staff
- Francisco Herrera (comics), comic book illustrator and co-creator of Mania