Francesco Grimaldi may refer to:

  • Francesco Maria Grimaldi (1618–1663), an Italian Jesuit priest, mathematician and physicist;
  • François Grimaldi (died 1309), called il Malizia ("the Cunning"), first ruler of Monaco and son of the Guelf Guglielmo Grimaldi;
  • Francesco Grimaldi (architect) (1543–1613), a Theatine priest and architect;
  • Francesco Ceva Grimaldi (historian) (1806–1864), an Italian historian, writer, and administrator;
  • Francesco Ceva Grimaldi (politician) (1831–1899), an Italian politician.