F80 may refer to:
Vehicles
;Aircraft
- Farman F.80, a French biplane
- Lockheed F-80 Shooting Star, an American jet fighter
- UL-Jih F80 Fascination, a Czech ultralight
;Automobiles
- BMW F80, a German high performance sedan
- Toyota Kijang (F80), a Japanese multi purpose vehicle
- Ferrari F80, limited production sports car built by Italian automotive manufacturer Ferrari
;Ships
- , a Blackwood-class frigate of the Royal Navy
- a Type 23 frigate of the Royal Navy
- , an R-class destroyer of the Royal Navy
- , a destroyer tender of the Royal Navy
Other uses
- Nikon F80, a SLR camera also known as the Nikon N80