Eusebius of Emesa (; ) was a learned Christian cleric of the Greek church, and a pupil of Eusebius of Caesarea. He was born in Edessa (in today's southeastern Turkey) and became the bishop of Emesa (in today's Syria). The Latin form of his name is Eusebius Emesenus.
After receiving his early education in his native town, he studied theology at Caesarea in Palestine and Antioch, and philosophy and science at Alexandria. Among his teachers were Eusebius of Caesarea and Patrophilus of Scythopolis.
Jerome praised his eloquence in De Viris Illustribus, comparing him favourably to Diodorus of Tarsus. The reputation he acquired for learning and eloquence led to his being offered the see of Alexandria in succession to the deposed Athanasius at the beginning of 339, but he declined, and the council of Antioch chose Gregory of Cappadocia, "a fitter agent for the rough work to be done." Eusebius accepted the small bishopric of Emesa (the modern Homs), but his powers as mathematician and astronomer led his flock to accuse him of practising sorcery, and he had to flee to Laodicea (the modern Latakia). A reconciliation was effected by the patriarch of Antioch, but tradition says that Eusebius finally resigned his charge and lived a studious life in Antioch.