thumb|upright=1.2|Asclepius and Epione with one of their sons on a 4th-century BC marble votive relief, [[Archaeological Museum of Patras, Greece.]]
In Greek mythology, Epione () is a minor health goddess, the wife of Asclepius, the Greek god of healing and medicine.
Mythology
Her name is derived from the word (, "soothing"). Epione was the personification of the soothing of pain and the care needed for recovery. She also had two sons, Machaon and Podalirius, who are mentioned in the Iliad of Homer as well as Telesphoros.
Epigraphical evidence suggests that Epione was a cultic figure in Athens, Epidauros, Kos, and Pergamon.