The Drôme (; ), a river in southeastern France, a left tributary of the Rhône. It is long, and has a watershed of 1,663 km<sup>2</sup>. Its source is in the western foothills of the Alps, near the village Valdrôme. It flows into the Rhône near Loriol-sur-Drôme, between Valence and Montélimar. Tributaries of the Drôme include the Bez (or Bès), the Roanne and the Gervanne.
The Drôme flows through the following départements and towns:
- Drôme (named after the river): Valdrôme, Luc-en-Diois, Die, Saillans, Allex, Crest, Loriol-sur-Drôme, Livron-sur-Drôme
- Ardèche : Le Pouzin