Denzil Holles may refer to:

  • Denzil Holles (MP) (c. 1538–1590) MP for East Retford
  • Denzil Holles, 1st Baron Holles (1599–1680), English statesman and writer
  • Denzil Holles, 3rd Baron Holles (1675–c. 1692), English statesman