Defoe may refer to:
People
- Defoe (surname), most notably English author Daniel Defoe
Places
- Defoe, Webster County, West Virginia, an unincorporated community
Other uses
- Defoe (comics), a zombie story
- Defoe Shipbuilding Company, a former shipyard in Bay City, Michigan
- Operation Defoe, a Second World War reconnaissance by the British Special Air Service
- Defoe (horse) (2014–2020), Thoroughbred racehorse
See also
- Dafoe (disambiguation)
- Foe (disambiguation)