Damascene may refer to:
- Topics directly associated with the city of Damascus in Syria:
- A native or inhabitant of Damascus
- Damascena, the territory around Damascus in Roman and Byzantine Syria
- Damascus Arabic, the local dialect of Damascus
- Damascus steel, developed for swordmaking
- "Damascene moment", the religious conversion of Paul
- Animal breeds:
- Damascene (pigeon)
- Damascus goat
- John of Damascus (c. 676-749), Syrian Christian monk and priest
- Materials technologies evoking the visual texture of Damascus steel:
- Damascening, of inlaying different metals into one another
- Damask, a reversible figured fabric
- Damascene patterning, a manufacturing process used to pattern copper into microchips