DFE or DfE may refer to:

Organizations

  • Department for the Economy, Northern Ireland
  • Department for Education, UK
  • DePatie–Freleng Enterprises, a defunct American animation studio

Science

  • Difluoroescaline, a psychedelic drug
  • Dilated fundus examination of the eye
  • Distribution of fitness effects
  • Dietary folate equivalent, bioavailability of folate
  • 1,1-Difluoroethane

Technology

  • Design-focused evaluation of educational quality
  • Design for the Environment of a product or service
  • DFE Ascender, an ultralight aircraft

Other

  • Dragon Fli Empire, a Canadian hip hop group
  • Dunfermline Town railway station, Scotland, National Rail station code
  • The Duke of Edinburgh's Award, commonly referred to as 'DofE'