Crosstalk refers to any signal or circuit unintentionally affecting another signal or circuit.

Crosstalk may also refer to:

Science and computing

  • Crosstalk (biology)
  • Crosstalk Mk.4, a communications application for PCs.

Arts and entertainment

  • Cross talk, a style of comedy used in performance by double acts
  • Xiangsheng, also translated as "crosstalk", a traditional Chinese comedic monologue or dialogue
  • Crosstalk (novel), a 2016 novel by American science fiction author Connie Willis
  • Crosstalk (film), a 1982 science fiction thriller film
  • Cross Talk, a 1980 album by the Pretty Things
  • Crosstalk: American Speech Music, a compilation album by the produced by Mendi + Keith Obadike
  • CrossTalk (TV series), a television program on the Russian-based international broadcaster RT
  • Cross Talk, a defunct radio show hosted by Indian RJ Balaji