County Route 583 (CR 583) is a county highway in the U.S. state of New Jersey. Its northern end is at an intersection with Route 27 in Princeton; its southern end is in a concurrency with U.S. Route 1 Business and U.S. Route 206 at an intersection with County Route 653 in Trenton.

The entire route is municipally-maintained

Past US 206, CR 583 becomes two-lane undivided Princeton Pike and continues through suburban residential neighborhoods. After an intersection with CR 546, the route passes business parks and widens into a divided highway as it reaches a cloverleaf interchange at I-295. This interchange has all movements except from southbound I-295 to southbound CR 583, which is provided by way of CR 546. Following this interchange, CR 583 becomes undivided again and heads into a mix of farms and woods. The road forms a brief concurrency with CR 569 as it heads into areas of woodland and residences. The road enters Princeton, where it becomes Mercer Street, and briefly gains a median prior to crossing CR 533. After this intersection, the route passes Princeton Battlefield State Park. Here, CR 583 passes through wooded residential areas as it comes to its northern terminus at Route 27 (Nassau Street) just to the east of Route 27's southern terminus at US 206.