Cooloola may refer to:
;Animals
- Cooloola (insect), a genus of the insect family Cooloolidae
- Cooloola monster (Cooloola propator), a species of the genus
- Cooloola sedge frog (Litoria cooloolensis)
;Places
- Cooloola Great Walk, 102 km coastal bushwalking route
- Cooloola, Queensland, a locality in the Gympie Region, Queensland, Australia
- Shire of Cooloola, Queensland, Australia (now part of Gympie Region)
;Other
- Cooloola Christian College, Gympie, Queensland
- Tillandsia 'Cooloola', a plant cultivar