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Contact dermatitis is a type of acute or chronic inflammation of the skin caused by exposure to chemical or physical agents. Irritant contact dermatitis is the most common type and represents 80% of all cases. It is caused by prolonged exposure to irritants, leading to direct injury of the epidermal cells of the skin, which activates an immune response, resulting in an inflammatory cutaneous reaction.

Epidemiology

Metanalysis of research on the incidence and prevalence of contact dermatitis suggests that as much as 20% of the general population is contact‐allergic to patch tests for common environmental allergens. Prevalence is lower in people under 18 years of age, and higher in women than in men.

Contact dermatitis constitutes 90%

Signs and symptoms

Contact dermatitis is a localized rash or irritation of the skin caused by contact with a foreign substance. Only the superficial regions of the skin are affected in contact dermatitis. Inflammation of the affected tissue is present in the epidermis (the outermost layer of skin) and the outer dermis (the layer beneath the epidermis).

Contact dermatitis results in large, burning, and itchy rashes. These can take anywhere from several days to weeks to heal. This differentiates it from contact urticaria (hives), in which a rash appears within minutes of exposure and then fades away within minutes to hours. Even after days, contact dermatitis fades only if the skin no longer comes in contact with the allergen or irritant. If contact dermatitis lasts for more than six weeks, either because exposure continues or the skin can't recover, it can be referred to as chronic. Symptoms of both irritant and allergic dermatitis include the following:

  • Red rash: This is the usual reaction. The rash appears immediately in irritant contact dermatitis;
  • Itchy, burning skin: Irritant contact dermatitis tends to be more painful than itchy, while allergic contact dermatitis often itches. whereas vesicles and bullae are seen in allergic contact dermatitis.
  • Lichenified lesions:

Common causes of allergic contact dermatitis include: nickel allergy, 14K or 18K gold, Balsam of Peru (Myroxylon pereirae), and chromium. In the Americas they include the oily, urushiol-containing coating from plants of the genus Toxicodendron: poison ivy, poison oak, and poison sumac. Millions of cases occur each year in North America alone. The alkyl resorcinols in Grevillea banksii and Grevillea 'Robyn Gordon' are responsible for contact dermatitis. Bilobol, another alkyl resorcinol found in Ginkgo biloba fruits, is also a strong skin irritant.

Common causes of irritant contact dermatitis include solvents, metalworking fluids, latex, kerosene, ethylene oxide, paper, especially papers coated with chemicals and printing inks, certain foods and drink, food flavorings and spices, perfumes and other fragrances used in cosmetics and cleaning products,

There are four types of contact dermatitis: irritant contact dermatitis; allergic contact dermatitis; protein contact dermatitis; and photo contact dermatitis. Photo contact dermatitis is divided into two categories: phototoxic and photoallergic.

Irritant contact dermatitis

The irritant's direct cytotoxic impact on epidermal keratinocytes causes Irritant contact dermatitis. Also, many plants directly irritate the skin.

Allergic contact dermatitis

thumb|Three-year-old girl with contact dermatitis, one day after contact with poison ivy

Allergic contact dermatitis (ACD) is accepted to be the most prevalent form of immunotoxicity found in humans, and is a common occupational and environmental health problem. By its allergic nature, this form of contact dermatitis is a hypersensitive reaction that is atypical within the population. The development of the disease occurs in two phases, which are induction and elicitation. and divided into two categories, phototoxic and photoallergic, PCD is the eczematous condition which is triggered by an interaction between a substance on the skin and ultraviolet light (320–400&nbsp;nm UVA) (ESCD 2006), therefore manifesting itself only in regions where the affected person has been exposed to such rays.

Without the presence of these rays, the photosensitiser is not harmful. For this reason, this form of contact dermatitis is usually associated only with areas of skin that are left uncovered by clothing, and it can be soundly defeated by avoiding exposure to sunlight. The mechanism of action varies from toxin to toxin, but is usually due to the production of a photoproduct. Toxins which are associated with PCD include the psoralens. Psoralens are in fact used therapeutically for the treatment of psoriasis, eczema, and vitiligo.

Photocontact dermatitis is another condition in which the distinction between forms of contact dermatitis is not clear-cut. Immunological mechanisms can also play a part, causing a response similar to ACD.

Protein contact dermatitis

Protein contact dermatitis (PCD) is a form of chronic eczema resulting from immediate hypersensitivity to plant, animal, or hydrolized proteins. It is most frequently seen in occupational settings involving food handling. PCD is diagnosed by prick tests.

Diagnosis

thumb|[[Patch test]]

Since contact dermatitis relies on an irritant or an allergen to initiate the reaction, it is important for the patient to identify the responsible agent and avoid it. This can be accomplished by having patch tests, one of various methods commonly known as allergy testing. The top three allergens found in patch tests from 2005 to 2006 were: nickel sulfate (19.0%), Myroxylon pereirae (Balsam of Peru, 11.9%), and fragrance mix I (11.5%). The patient must know where the irritant or allergen is found to be able to avoid it. It is important to also note that chemicals sometimes have several different names, and do not always appear on labels.

The distinction between the various types of contact dermatitis is based on a number of factors. The morphology of the tissues, the histology, and immunologic findings are all used in diagnosis of the form of the condition. However, as suggested previously, there is some confusion in the distinction of the different forms of contact dermatitis. Using histology on its own is insufficient, as these findings have been acknowledged not to distinguish,

Topical antibiotics should not be used to prevent infection in wounds after surgery. When they are used, it is inappropriate, and the person recovering from surgery is at significantly increased risk of developing contact dermatitis. applied for 30 minutes, three times a day can offer relief.

  • Calamine lotion may relieve itching.