Coca wine is an alcoholic beverage combining wine with cocaine. One popular brand was Vin Mariani, developed in 1863 by French chemist and entrepreneur Angelo Mariani.
At the end of the 19th century, the fear of drug abuse made coca-based drinks less popular. This led to the prohibition of cocaine in the United States in 1914 via the Harrison Narcotics Tax Act, and the removal of cocaine from coca wine, though coca leaf remained. Studies suggest the compound decreases the feelings of drunkenness from alcohol alone and heightens euphoric sensations, but is also potentially cardiotoxic, more so than either cocaine or alcohol alone.