Clayoquot is an anglicization of the Nuu-chah-nulth language name "Tla-o-qui-aht", one of the indigenous tribes of the region so named. It may refer to:
- Clayoquot, British Columbia, historically also known as Port Cox, a community on Stubbs Island, just northwest of Tofino, British Columbia
- Clayoquot Sound and the associated region, including:
- the Clayoquot River
- Clayoqua 6, an Indian Reserve at the mouth of that river
- Clayoquot Arm Provincial Park
- Clayoquot Plateau Provincial Park
- the Tla-o-qui-aht First Nations, a band government of the Nuu-chah-nulth peoples, incorporating a number of historical tribes including:
- the Tla-o-qui-aht people (the two other groups comprising the Tla-o-qui-aht First Nations are the Hesquiaht and the Ahousaht)
- , a Canadian minesweeper sunk in World War II
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