Choptank may refer to a location in the eastern United States or a former Native American tribe:
- Choptank people
;Communities
- Choptank, Maryland, Caroline County
- Choptank Mills, Delaware, Kent County
;Other
- Choptank (Middletown, Delaware), listed on the National Register of Historic Places listings in southern New Castle County, Delaware
- Choptank Electric Cooperative, a not-for-profit energy organization
- Choptank River, a tributary of Chesapeake Bay
- Choptank River Fishing Pier, on the Choptank River
- Choptank River Light, a lighthouse near Oxford, Maryland
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