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Chop, CHOP, Chops, or CHOPS may refer to:

Medicine

Children's Hospital of Philadelphia, one of the largest and oldest children's hospitals in the world
CHOP (chemotherapy), a chemotherapy treatment for non-Hodgkin's lymphoma
DNA damage-inducible transcript 3, a genetic protein also known as "CHOP", for "C/EBP-homologous protein"

Embouchure, in music, a synonym for chops (and later, more broadly, musical skill or ability)
CHOPS, an Asian-American hip hop producer, rapper and member of rap group Mountain Brothers
Chops (Euros Childs album), 2006
Chops (Joe Pass album), 1978

Chop Robinson (born 2003), American football player
Chop (wrestling), a move in professional wrestling
Chops (juggling), a juggling pattern using three balls or clubs
Knifehand strike, also known as a karate chop, a fast and focused strike with the side of the hand
Backspin, a shot such that the ball rotates backwards after it is hit, especially in table tennis or other racket sports
Chop block (gridiron football), a now-illegal blocking technique

Chop, Ukraine, a city
Chop railway station
Meat chop, a cut of meat usually containing a rib and served as an individual portion
Seal (East Asia), or "chop" colloquially, used in East Asia to prove identity
Chop (film), a 2011 American horror film
Chop (fiberglass), a form of fiberglass
Cold heavy oil production with sand, a technique for extracting difficult heavy crude oil
Capitol Hill Occupied Protest, a short-lived self-proclaimed autonomous zone in Seattle