Chlortetracycline (trade name Aureomycin, Lederle Laboratories) is a tetracycline antibiotic, the first tetracycline to be identified. It was discovered in 1945 at Lederle Laboratories under the supervision of Yellapragada Subbarow and Benjamin Minge Duggar. They were helped by Louis T. Wright, a surgeon who conducted this medication's first human trials. Duggar identified the antibiotic as the product of an actinomycete he cultured from the soil of Sanborn Field at the University of Missouri. The organism was named Streptomyces aureofaciens and the isolated drug, Aureomycin, because of the molecule's intense golden-yellow color.
Medical uses
A combination cream with triamcinolone acetonide is available for the treatment of infected allergic dermatitis in humans. dogs and horses. It is also used to treat infected wounds in cattle, sheep and pigs, and respiratory tract infections in calves, pigs and chickens.
Contraindications
Chlortetracycline for systemic use is contraindicated in animals with severe hepatic or renal impairment. Topical chlortetracycline must not be used on the udder of animals whose milk is intended for human consumption.