The Chena River (; "river of something (game)") is a tributary of the Tanana River in the Interior region of the U.S. state of Alaska. It flows generally west from the White Mountains to the Tanana River near the city of Fairbanks, which is built on both sides of the river. The Tanana empties into the long Yukon River.

Named tributaries of the Chena River include the North Fork, South Fork, West Fork, Middle (East) Fork and the Little Chena River.

Fish

The Chena River supports populations of many fish species, including Arctic grayling, burbot, chum salmon, humpback whitefish, king salmon, least cisco, longnose suckers, northern pike, round whitefish, and sheefish. Easily accessible from Fairbanks, the Chena is the most popular sport-fishing river in interior Alaska.