Charles Metcalfe may refer to:
- Charles Metcalfe, 1st Baron Metcalfe (1785–1846), British colonial administrator
- Charles Metcalfe (British Army officer) (1865–1912), British general
- Charles Russell Metcalfe (1904–1991), English botanist
See also
- Charles D. Metcalf (born 1933), United States Air Force general
- Metcalfe (surname)