Cghene, is the supreme god of the Urhobo and Isoko people in southern Nigeria. He is believed to have created the world and all peoples. Cghene is beyond human comprehension and is only known by his actions. Because the god is so distant and unknown, he has no temples or priests and no prayers or sacrifices are offered directly to him.

Cghene has a courier named Oyise, who is referred to as uko Cghene or "messenger of Cghene".