Cenci () is an Italian surname derived from the medieval given name Cencio. Notable people with the name include:
- , a noble family of Renaissance Rome, including:
- Beatrice Cenci (1577–1599), Italian noblewoman and parricide
- (1676–1740), Italian cardinal
- Athina Cenci (born 1946), Greek-Italian actress and comedian
- Antinisca Cenci (born 1978), Italian equestrian
- Baldassare Cenci (seniore) (1648–1709), Italian Roman Catholic cardinal
- Baldassare Cenci (iuniore) (1710–1763), Italian Roman Catholic cardinal
- Cecilia Cenci (1942–2014), Argentinian actress
- Christian Cenci (born 1998), Italian football player
- Gaspare Cenci (), Italian Roman Catholic prelate
- Giuliano Cenci (1931–2018), Italian animated film director
- John Cenci (born 1934), American football player
- Massimo Cenci (born 1967), Sammarinese politician
- Matías Cenci (born 1978), Argentine football player
- Mirco Cenci (born 1957), Italian sports shooter
See also
- The Cenci, a drama by Percy Shelley based on Beatrice's murder of her father
- The Cenci (opera), an opera adaptation by Havergal Brian
- Les Cenci, a drama adaptation by Antonin Artaud
- Beatrice Cenci (disambiguation)
- Beatrix Cenci, Alberto Ginastera's opera
- Lungotevere De' Cenci, Rome
- Cenci Journalism Project (), which aims to use multilingual and global sources in Chinese journalism
- Censi (surname)