Cayuse is a census-designated place (CDP) and unincorporated community in Umatilla County, Oregon, United States, located east of Pendleton on the Umatilla Indian Reservation. As of the 2020 census, Cayuse had a population of 66. It is part of the Pendleton–Hermiston Micropolitan Statistical Area.

Served by a railroad station and post office, the area was named for the Cayuse people. The post office was established in 1867

Geography

According to the United States Census Bureau, the CDP has a total area of , all land.

Demographics

As of the census