Caué is a district of São Tomé and Príncipe, on São Tomé Island. Covering , it is the largest of the nation's seven districts in terms of area. In population it is the smallest, with 6,031 residents (2012). The district seat is São João dos Angolares. It is divided into the two statistical subdistricts São João dos Angolares and Malanza. The most notable natural landmark is the volcanic vent Pico Cão Grande.

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