Caleb Smith may refer to:
- Caleb Blood Smith (1808–1864), American journalist and politician
- Caleb Smith (skeleton racer) (born 1983), American skeleton racer
- Caleb Smith (baseball) (born 1991), American baseball pitcher
- Caleb L. Smith (1829–1890), American builder and politician from New York
- Caleb Smith, protagonist in Ex Machina (film)