Caisson (French for "box") may refer to:
- Caisson (engineering), a sealed underwater structure
- Caisson (vehicle), a two-wheeled cart for carrying ammunition, also used in certain state and military funerals
- Caisson (Asian architecture), a spider web ceiling
- Caisson (lock gate), a gate for a dock or lock, constructed as a floating caisson
- Caisson (pen name), of Edward Sperling
- Caisson (western architecture), a type of coffer
- Caisson disease, or decompression sickness
- Caisson lock, a type of canal lock
See also
- Caisson foundation
- Kazon, a fictional alien race in Star Trek
- Khe Sanh