The Caenophidia are a derived clade of alethinophidian snakes, which contains over 80% of all the extant species of snakes. The largest family is Colubridae, but it also includes at least seven other families, Hence Caenophidia is usually considered to comprise Acrochordidae plus the more derived snakes classified as Colubroidea. Recent molecular studies have also found the families Xenophidiidae and Bolyeriidae to be closely related to caenophidians, forming the sister group to Caenophidia rather than being part of Henophidia.

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