Buffington may refer to:
Places in the United States
;Communities
- Buffington, Georgia
- Buffington, Missouri
- Buffington Township, Indiana County, Pennsylvania
;Landmarks
- Buffington Harbor, Gary, Indiana
- Buffington Hotel, a historic building in Westville, Oklahoma
- Buffington Island, in the Ohio River, between West Virginia and Ohio
- Battle of Buffington Island, a battle of the American Civil War
People
- Buffington (surname)