Brandywine is the name of an unincorporated area in Prince George's County, Maryland, United States, that refers both to a census-designated place (CDP) and a zip code area which is much larger (20613), whose areas overlap. The population of Brandywine at the 2020 U.S. census was 10,550 for the CDP, and the population of ZIP code 20613 was 11,860 in 2010.

Brandywine is in the southernmost area of Prince George’s County, surrounded by a rural setting. It is in the Southern Maryland region. Brandywine is also a suburb of two cities: it lies within the outer suburban Washington D.C. area and is also a close suburb of Waldorf.

Geography

The CDP and town are adjacent to the southern border of Prince George's County, lying east and west of busy Maryland Route 5/U.S. Route 301, which merge at Brandywine. Brandywine CDP is bordered by Accokeek to the west, Clinton and Rosaryville to the north, Croom to the northeast, and Cedarville to the southeast, all in Prince George's County. Waldorf in Charles County borders Brandywine to the south. The Brandywine zip code area encompasses parts of both counties and includes Cedarville and Baden.

Designated as part of the Prince George's County rural tier, it is primarily rural with a suburban and commercial center.

Demographics