thumb|An [[Eastern Orthodox Church|Eastern Orthodox cross]]
April 22 - Eastern Orthodox liturgical calendar - April 24
All fixed commemorations below are observed on May 6 by Eastern Orthodox Churches on the Old Calendar.
For April 23, Orthodox Churches on the Old Calendar commemorate the saints listed on April 10.
Saints
- Martyrs Donatus and Therinus of Bothrotus, in Epirus (c. 250)
- <em>Holy Glorious Great-martyr and Victory-bearer and Wonderworker George</em> (303)
- Martyr Polychronia, mother of Great-martyr Saint George, a Greek native of Lydda (Diospolis) (303)
- <em>Martyrs Anatolius and Protoleon</em>, soldiers converted by witnessing the martyrdom of St. George; and martyrs Glycerius and Athanasius the Magician, at Nicomedia (303)
- Martyr Alexandra the Empress, wife of Diocletian (303) <small>(see also: April 21)</small>
Pre-Schism Western saints
- Martyrs Felix, Fortunatus, and Achilleus, at Valence in France (212)
