thumb|An [[Eastern Orthodox Church|Eastern Orthodox cross]]
April 21 - Eastern Orthodox liturgical calendar - April 23
All fixed commemorations below are observed on May 5 by Eastern Orthodox Churches on the Old Calendar.
For April 22nd, Orthodox Churches on the Old Calendar commemorate the Saints listed on April 9.
Saints
- Holy Apostle Nathaniel of the Twelve (Bartholomew) (1st century)
- Apostles Apelles, Luke (not the Evangelist), and Clement, of the Seventy (1st century)
- Martyr Nearchus, by fire (3rd century)
- Venerable Theodore the Sykeote, Bishop of Anastasiopolis in Galatia (613)
