thumb|An [[Eastern Orthodox Church|Eastern Orthodox cross]]

April 20 - Eastern Orthodox liturgical calendar - April 22

All fixed commemorations below are observed on May 4 by Eastern Orthodox Churches on the Old Calendar.

For April 21, Orthodox Churches on the Old Calendar commemorate the Saints listed on April 8.

Saints

  • Martyrs Theodore of Perge in Pamphylia, his mother Philippa, and Dioscorus, Socrates, and Dionysius (c. 138-161) <small>(see also: April 19 - Greek)</small>
  • Martyr Alexandra the Empress, wife of Diocletian, and those with her (303): <small>(see also: April 23)</small>

:* Martyrs Isaacius, Apollo, and Codratus, of Nicomedia.

  • Hieromartyrs Januarius, Bishop of Benevento, and his companions (c. 305)

:* Faustus, Proclus, and Sosius, Deacons;

:* Desiderius, Reader; and

:* Eutychius, and Acutius, laymen, at Pozzuoli.

  • Saint Maximianus, Archbishop of Constantinople (434) <small>(see also: November 17)</small>
  • Venerable Anastasius Sinaita, Abbot of the Monastery of St. Catherine at Sinai (c. 700) <small>(see also: April 20 - Slavic)</small>
  • Martyr Karol (Charles)

Pre-Schism Western saints

  • Saint Cyprian, Bishop of Brescia (582)
  • Saint Beuno, Abbot, of Clynnog Fawr, Wales (642)
  • Saint Maelruba of Apur Crossan (Maelrubius, Maolrubha), Ireland (722)
  • Saint Frodulphus (Frou), a monk at St Martin's in Autun (c. 750)
  • Venerable Jacob (Jakov, James), Abbot of Stromynsk Monastery, Radonezh (1392)
  • Saint Alexis, Priest of, Bortsurmany, Nizhny Novgorod (1848)

New martyrs and confessors

  • New Hieromartyr John Prigorovsky, Priest (1918) <small>(see also: May 4)</small>

Other commemorations

  • Synaxis of The Mozdok Icon of the Mother of God (Mozdokskaya) (1768)
  • Uncovering of the relics (1999) of St. Theodore, Abbot of Sanaxar Monastery (1791)