Apalachicola may refer to:
- Apalachicola band, an association of Native American towns along the Apalachicola River in Florida in the early 19th century
- Apalachicola Province, an association of Native American towns on the Chattahoochee River in Alabama and Georgia that became the Lower Towns of the Muscogee Confederacy
- Apalachicola (tribal town), a Native American town that was the namesake of the Apalachicola Province
Places
- Apalachicola, Florida
- Apalachicola River
- Apalachicola Bay
- Apalachicola National Forest
- Apalachicola Regional Airport
- Port of Apalachicola
Railroad
- Apalachicola and Alabama Railroad
- Apalachicola Northern Railroad
Ships
- , a tugboat in the United States Navy.