Antisuyu ( , ; ) was the eastern part of the Inca Empire which bordered on the modern-day Upper Amazon region which the Anti inhabited. Along with Chinchaysuyu, it was part of the Hanan Suyukuna or "upper quarters" of the empire, constituting half of the Tahuantinsuyu, the "four parts bound together" that comprised the empire. Indeed, it is the root of the word "Andes". 'Anti' is the likely origin of the word 'Andes', Spanish conquerors generalized the term and named all the mountain chain as 'Andes', instead of only the eastern region, as it was the case in Inca era. According to some sources, Antisuyu was not the smallest of the Incan , citing that its territory may have included the eastern slope of the Tahuantinsuyu as well as the adjoining tropical lowlands along the length of the empire.
The region of Antisuyu was the final retreat of the Neo-Inca state as they fled Spanish conquest. Notable among the Inca settlements here were Vilcabamba, and Vitcos. It is also thought that the mythical city of Paititi may exist somewhere within this region. Historian Andrew Nicol published research in 2009 in which he concluded that the existence of a city such as Paititi is possible within the Peruvian Amazon Basin. Research as recent as 2016 by Vincent Pélissier provides a possible location for the lost city to the northeast of Vilcabamba.
Annexation
Antisuyu was previously not part of the Incan empire. It was later conquered to address the problem of the shrinking space for crops along the coastal region of the empire.
Wamani
thumb|right|The four of the Inca empire. Antisuyu appears in green.
Each was divided into , or provinces. Antisuyu included the of: