Aleksei Semyonovich Shein (; 1662 – February 12, 1700) was a Russian commander and statesman, the first Russian Generalissimo (1696), boyar, great-grandson of Mikhail Shein.
Shein originated from an old boyar family, which, however, after the execution of Mikhail Shein in 1634 was exiled to Alatyrsky Uyezd, currently Chuvashia, and were only allowed to return to Moscow in 1642.