Al-Wazir () is an Arabic language surname. Notable people with the surname include:
- Intissar al-Wazir (1941), member of the Palestinian Legislative Council and a former PNA minister
- Kamel al-Wazir, Transport Minister of Egypt
- Khalil al-Wazir (1935–1988), Palestinian leader and co-founder of the nationalist party Fatah
- Tarek Al-Wazir (1971), politician in the German Green Party