Acyclic may refer to:
- In chemistry, a compound which is an open-chain compound, e.g. alkanes and acyclic aliphatic compounds
- In mathematics:
- A graph without a cycle, especially
- A directed acyclic graph
- An acyclic complex is a chain complex all of whose homology groups are zero
- An acyclic sheaf is a sheaf all of whose higher sheaf cohomology groups are zero
- An acyclic space is a topological space all of whose homology groups are zero
- In economics, an economic indicator with little or no correlation to the business cycle