AFS is an initialism that may refer to:
Aviation
- Aeronautical fixed service, for air navigation
- Air force station
- IATA airport code for Zarafshan Airport in Navoiy Region, Uzbekistan
Computing
- Andrew File System, a distributed networked file system
- OpenAFS, an open source implementation of the Andrew File System
- Apple File Service, implementing the Apple Filing Protocol
- Apple File System, Apple's proprietary file system
- AtheOS File System, part of the Syllable operating system
Education
- Abington Friends School, in Jenkintown, Pennsylvania, United States
- AFS Intercultural Programs, formerly American Field Service
- Akwesasne Freedom School, in New York, United States (Awkewsasne)
Military
- Army Fire Service, UK
- A US Navy hull classification symbol: Combat Stores Ship (AFS)
Organizations
- Alternative for Sweden, a political party in Sweden
- American Folklore Society
- American Foundry Society
- (AfS), a workgroup of the German National Library (DNB)
- Association of Football Statisticians, UK
- Australian Flag Society
- Auxiliary Fire Service, UK and Ireland
Places
- Afs, Idlib, a Syrian village
- Ashford railway station (Surrey) (station code:AFS), Middlesex, UK
- South Africa, ITU country code
Other
- Advanced front-lighting system (AFS) or Adaptative Front-lighting System, for automotive headlamps
- Afghan afghani, unit of currency
- Afro-Seminole Creole language (ISO 639-3: oafs)
- "AFS", a song by Natanael Cano from Nata Montana, 2023
- AFS Trinity, a US company
- Allergic fungal sinusitis
- Alternative financial service
- American Foursquare, a style of house
- Atomic fluorescence spectroscopy
- Available for sale, an accounting term
- International Convention on the Control of Harmful Anti-fouling Systems on Ships, 2001
- Nikon AF-S, a type of Nikon F-mount lens