The 2005 MLS SuperDraft, held in Baltimore, Maryland, on January 14, 2005, was the sixth incarnation of the annual MLS SuperDraft. Expansion club Real Salt Lake had the first pick as the result of a coin toss (fellow newcomers C.D. Chivas USA got to go first in the expansion draft). RSL drafted Under-17 midfielder Nikolas Besagno with the first selection.

A collective bargaining agreement with the MLS Players' Union dictated that the draft be reduced from six to four rounds, although a supplemental draft was held to equip newly formed reserve teams and compensate for expansion.

Player selection

thumb|[[Chivas USA selected Brad Guzan 2nd overall. The 2007 MLS Goalkeeper of the Year is a 2x MLS All-Star and named to the 2007 MLS Best XI. He earned 64 caps with the US Men's National Team and was selected to the 2010 and 2014 FIFA World Cup squads.]]

thumb|[[FC Dallas selected Drew Moor 6th overall. The 2015 MLS All-Star is a member of 400 games played club and holds the record for the most consecutive games played by a field player at 68 matches.]]

thumb|[[New England Revolution|New England selected Michael Parkhurst 9th overall. The 2005 MLS Rookie of the Year is a 6x All-Star and in 2007 won the MLS Defender of the Year and was named to the MLS Best XI.]]

;Key

{| class="wikitable"

| style="background:#FFCC00"|*

| Denotes a player contracted under the Generation Adidas program

|-

| style="background:#CFECEC"| ^

| Denotes player who has been selected to an MLS All-Star Game

|-

| style="background:#CCFF99"|§

| Denotes a player who won the MLS Rookie of the Year

|-

| style="background: #FBCEB1"| †

| Denotes player who has been selected for an MLS Best XI team

|-

| style="background:#FFFF99"| ~

|Denotes a player who won the MLS MVP

|-

|}

Round one

{| class="wikitable sortable" border="1"

|-

! width=7%| Pick # !! width=30% | MLS Team !!width=25% | Player !! width=10% | !!| Affiliation

|-

|1|| Real Salt Lake || style="background:#FFCC00"| Nikolas Besagno* || M || Generation Adidas

|-

|2|| Chivas USA || bgcolor="#FBCEB1" | Brad Guzan*^† || GK || University of South Carolina

|-

|3|| Chicago Fire || style="background:#FFCC00"| Chad Barrett* || F || UCLA

|-

|4|| San Jose Earthquakes