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The following lists events that happened during 1999 in South Africa.
Incumbents
- President:
- Nelson Mandela (until 16 June).
- Thabo Mbeki (from 16 June).
;October
- 22 – Henry Navigator, a 13,000 ton Cyprus bulk carrier, sinks off Bok Point about 35 km north of Cape Town.
- 23 – A South African Air Force Oryx helicopter crashes near Kroonstad, killing 10 people and injuring 14 others.
- Queen Elizabeth II and The Duke of Edinburgh visit South Africa.
- The Greater St. Lucia Wetland Park is declared a UNESCO World Heritage Site.
;November
- 15 – Afrikaans language television channel kykNET is launched.
;December
- 3 – Government signs the final purchasing agreement in the arms deal and the loan agreement to pay for the equipment is signed by Finance Minister Trevor Manuel.
;Unknown Date
- Statistics South Africa conducts a Survey of Activities of Young People.
Births
- 25 January - Ndavi Nokeri, Miss South Africa 2022
- 16 February – Chloe Meecham, water polo player
- 20 February - Boohle, singer
- 3 March - Sphephelo Sithole, soccer player
- 2 April – Elaine, singer and songwriter
- 26 April - Laura Wolvaardt, cricket player
- 22 May - Bongeka Gamede, soccer player
- 11 June - Paballo Mavundla, actor
- 29 November - Kamo Mphela, dancer and singer
- Masego Kgomo, muti murder victim. (d. 2009)
Deaths
- 10 January – Gavin Relly, businessman and Chairman of Anglo American. (b. 1926)
- 26 May – David Millin, 78, movie director, producer, and cinematographer (b. 1920)
- 27 July – Simon "Mahlathini" Nkabinde, mbaqanga singer (b.1938)
- 15 November – Pieter van der Byl, politician (b. 1923)
