The 1990–91 network television schedule for the four major English language commercial broadcast networks in the United States covers primetime hours from September 1990 through August 1991. The schedule is followed by a list per network of returning series, new series, and series cancelled after the 1989–90 season.
Beginning this season, Fox began broadcasting on Thursdays and Fridays.
PBS is not included; member stations have local flexibility over most of their schedules and broadcast times for network shows may vary.
New series are highlighted in bold.
All times are U.S. Eastern Time and Pacific Time (except for some live sports or events). Subtract one hour for Central, Mountain, Alaska and Hawaii–Aleutian times.
Each of the 30 highest-rated shows is listed with its rank and rating as determined by Nielsen Media Research.
Legend
Sunday
{| class="wikitable" style="width:100%;margin-right:0;text-align:center"
|-
! colspan="2" style="background-color:#C0C0C0;text-align:center"|Network
! style="background-color:#C0C0C0;text-align:center"|7:00 p.m.
! style="background-color:#C0C0C0;text-align:center"|7:30 p.m.
! style="background-color:#C0C0C0;text-align:center"|8:00 p.m.
! style="background-color:#C0C0C0;text-align:center"|8:30 p.m.
! style="background-color:#C0C0C0;text-align:center"|9:00 p.m.
! style="background-color:#C0C0C0;text-align:center"|9:30 p.m.
! style="background-color:#C0C0C0;text-align:center"|10:00 p.m.
! style="background-color:#C0C0C0;text-align:center"|10:30 p.m.
|-
! colspan="2"|ABC
| colspan="2"|Life Goes On
| style="background:#FFFF00;"|America's Funniest Home Videos
| style="background:#FFFF00;"|America's Funniest People
| colspan="4" style="background:#FA8072;"|The ABC Sunday Night Movie
|-
! rowspan="5"|CBS
! Fall
| style="background:#6699CC;" rowspan="5" colspan="2"|
| style="background:#00FFFF;" rowspan="3" colspan="2"|Murder, She Wrote
| style="background:#FA8072;" rowspan="3" colspan="4"|
|-
! Winter
|-
! Spring
|-
! Summer
| style="background:#C0C0C0;"|All in the Family
| Sunday Dinner
| style="background:#00FFFF;" colspan="2"|Murder, She Wrote
| colspan="2"|The Trials of Rosie O'Neill
|-
! Mid-summer
| style="background:#00FFFF;" colspan="2"|Murder, She Wrote
| style="background:#FA8072;" colspan="4"|
|-
! rowspan="5"|Fox
! Fall
| rowspan="5"|True Colors
| rowspan="5"|Parker Lewis Can't Lose
| rowspan="5"|In Living Color
| rowspan="5"|Get a Life
| rowspan="5"|Married... with Children
| rowspan="3"|Good Grief
| colspan="2"|Against the Law
|-
! Mid-fall
| colspan="2" rowspan="2"|Comic Strip: Live
|-
! Winter
|-
! Spring
|Top of the Heap
| colspan="2" rowspan="2"|The Sunday Comics
|-
! Summer
| style="background:#C0C0C0;"|Married... with Children
|-
! rowspan="5"|NBC
! Fall
| colspan="2"|Hull High
| colspan="2"|Lifestories
| rowspan="5" colspan="4" style="background:#FA8072;"|NBC Sunday Night Movie
|-
! Winter
| colspan="2" style="background:#6699CC;"|Sunday Best
| style="background:#6699CC;"|Real Life with Jane Pauley
| style="background:#6699CC;"|Expose
|-
! Spring
| colspan="2" |The 100 Lives of Black Jack Savage
| rowspan="3" style="background:#6699CC;"|Expose
| rowspan="3" style="background:#6699CC;"|Real Life with Jane Pauley
|-
! Summer
| colspan="2" |C. Everett Koop, M.D.
|-
! Mid-summer
| style="background:#FA8072;" colspan="2"|
|}
Note: All in the Family consisted in assorted episodes of the 1970s series.
Monday
{| class="wikitable" style="width:100%;margin-right:0;text-align:center"
|-
! colspan="2" style="background-color:#C0C0C0;text-align:center"|Network
! style="background-color:#C0C0C0;text-align:center"|8:00 p.m.
! style="background-color:#C0C0C0;text-align:center"|8:30 p.m.
! style="background-color:#C0C0C0;text-align:center"|9:00 p.m.
! style="background-color:#C0C0C0;text-align:center"|9:30 p.m.
! style="background-color:#C0C0C0;text-align:center"|10:00 p.m.
! style="background-color:#C0C0C0;text-align:center"|10:30 p.m.
|-
! rowspan="4"|ABC
! Fall
| rowspan="4" colspan="2"|MacGyver
| style="background:lightgreen;" colspan="4"|
|-
! Winter
| rowspan="3" colspan="4" style="background:#FA8072;"|The ABC Monday Night Movie
|-
! Spring
|-
! Summer
|-
! rowspan="6"|CBS
! Fall
| Uncle Buck
| rowspan="4" style="background:#00FFFF;"|Major Dad
| rowspan="6" style="background:#FFFF00;"|Murphy Brown
| rowspan="4" style="background:#FFFF00;"|Designing Women
| rowspan="3" colspan="2"|The Trials of Rosie O'Neill
|-
! Mid-fall
| rowspan="3"|Evening Shade
|-
! Winter
|-
! Spring
| rowspan="3" colspan="2"|Northern Exposure
|-
! Summer
| style="background:#00FFFF;"|Major Dad
| style="background:#FA8072;"| The Family Man
|Evening Shade
|-
! Mid-summer
|Evening Shade
| style="background:#00FFFF;"|Major Dad
| style="background:#FFFF00;"|Designing Women
|-
! colspan="2"|Fox
| colspan="4" style="background:#FA8072;"|Fox Night at the Movies
| style="background:#abbfff;" colspan="2"|
|-
! rowspan="4"|NBC
! Fall
| rowspan="4"|The Fresh Prince of Bel-Air
| Ferris Bueller
| rowspan="4" colspan="4" style="background:#FA8072;"|NBC Monday Night at the Movies
|-
! Winter
| rowspan="3"|Blossom
|-
! Spring
|-
! Summer
|}
Note: On CBS, Face to Face with Connie Chung was to have aired 10-11 p.m., but it was replaced by The Trials of Rosie O'Neill at the last minute due to Connie Chung's personal health commitments.
Tuesday
{| class="wikitable" style="width:100%;margin-right:0;text-align:center"
|-
! colspan="2" style="background-color:#C0C0C0;text-align:center"|Network
! style="background-color:#C0C0C0;text-align:center"|8:00 p.m.
! style="background-color:#C0C0C0;text-align:center"|8:30 p.m.
! style="background-color:#C0C0C0;text-align:center"|9:00 p.m.
! style="background-color:#C0C0C0;text-align:center"|9:30 p.m.
! style="background-color:#C0C0C0;text-align:center"|10:00 p.m.
! style="background-color:#C0C0C0;text-align:center"|10:30 p.m.
|-
! rowspan="7"|ABC
! Fall
| style="background:#FF66FF;" rowspan="3"|Who's the Boss?
| style="background:#FF66FF;"|Head of the Class
| style="background:#FFFF00;" rowspan="7"|Roseanne
| style="background:#00FFFF;" rowspan="3"|Coach
| colspan="2" rowspan="2"|Thirtysomething
|-
! Winter
| style="background:#FF66FF;" rowspan="2"|Davis Rules
|-
! Spring
| colspan="2"|Eddie Dodd
|-
! Mid-spring
| style="background:#FF66FF;"|Baby Talk
| style="background:#FF66FF;" |Who's the Boss?
| Stat
| colspan="2"|Thirtysomething
|-
! Summer
| style="background:#FF66FF;" rowspan="2"|Who's the Boss?
| style="background:#FA8072;"|Head of the Class
| style="background:#00FFFF;" rowspan="3"|Coach
| style="background:#FA8072;" colspan="2"|China Beach
|-
! Mid-summer
| style="background:#FF66FF;" |Davis Rules
| rowspan="2" colspan="2"|Thirtysomething
|-
! Late summer
| style="background:#C0C0C0;"|Full House
| style="background:#FF66FF;"|Who's the Boss?
|-
! colspan="2"|CBS
| style="background:#FF66FF;" colspan="2"|Rescue 911
| colspan="4" style="background:#FA8072;"|CBS Tuesday Night Movie
|-
! rowspan="5" |NBC
! Fall
| style="background:#00FFFF;" colspan="2" rowspan="5" |Matlock
| style="background:#00FFFF;" colspan="2" rowspan="5" |In the Heat of the Night
| colspan="2" style="background:#C0C0C0;"|
|-
! Mid-fall
| colspan="2" rowspan="2"|Law & Order
|-
! Winter
|-
! Spring
| colspan="2"|Shannon's Deal
|-
! Summer
| colspan="2"|Law & Order
|}
Wednesday
{| class="wikitable" style="width:100%;margin-right:0;text-align:center"
|-
! colspan="2" style="background-color:#C0C0C0;text-align:center"|Network
! style="background-color:#C0C0C0;text-align:center"|8:00 p.m.
! style="background-color:#C0C0C0;text-align:center"|8:30 p.m.
! style="background-color:#C0C0C0;text-align:center"|9:00 p.m.
! style="background-color:#C0C0C0;text-align:center"|9:30 p.m.
! style="background-color:#C0C0C0;text-align:center"|10:00 p.m.
! style="background-color:#C0C0C0;text-align:center"|10:30 p.m.
|-
! rowspan="8"|ABC
! Fall
| style="background:#FF66FF;" rowspan="7"|The Wonder Years
| style="background:#FF66FF;" rowspan="7"|Growing Pains
| style="background:#FF66FF;" rowspan="8"|Doogie Howser, M.D.
| rowspan="2"|Married People
| colspan="2"|Cop Rock
|-
! Winter
| rowspan="2" colspan="2"|Equal Justice
|-
! Mid-winter
| Anything but Love
|-
! Spring
| My Life and Times
| colspan="2"|Gabriel's Fire
|-
! Mid-spring
| Anything but Love
| rowspan="3" colspan="2"|American Detective
|-
! Summer
| The Man in the Family
|-
! Mid-summer
| style="background:#C0C0C0;" rowspan="2"|Davis Rules
|-
! Late summer
| style="background:#C0C0C0;"| Dinosaurs
| style="background:#FF66FF;" |The Wonder Years
| Anything but Love
| Married People
|-
! rowspan="7"|CBS
! Fall
| Lenny
| Doctor Doctor
| rowspan="7" colspan="2"|Jake and the Fatman
| rowspan="3" colspan="2"|WIOU
|-
! Mid-fall
| rowspan="2" colspan="2" style="background:#77AACC;"|48 Hours
|-
! Winter
|-
! Mid-spring
| colspan="2" style="background:#FA8072;"|
| rowspan="4" colspan="2" style="background:#77AACC;"|48 Hours
|-
! Summer
| style="background:#C0C0C0;"|Rescue 911
| rowspan="2" style="background:#FA8072;"| The Family Man
|-
! Mid-summer
|style="background:#FA8072;"| The Hogan Family
|-
! Late summer
| style="background:#C0C0C0;"|Police Squad!
| Morton & Hayes
|-
! rowspan="7"|NBC
! Fall
| style="background:#00FFFF;" colspan="2" rowspan="7"|Unsolved Mysteries
| The Fanelli Boys
| Dear John
| colspan="2" rowspan="4"|Hunter
|-
! Mid-fall
| rowspan="2"|Dear John
| The Fanelli Boys
|-
! Late fall
| Working It Out
|-
! Winter
| rowspan="4"|Night Court
| Seinfeld
|-
! Spring
| rowspan="2"|Dear John
| colspan="2" rowspan="3"|Quantum Leap
|-
! Summer
|-
! Mid-summer
| Seinfeld
|}
Note: Top Cops aired at 10:00 PM on CBS from July to October 1990. Police Squad! on CBS consisted of reruns of the 1982 ABC series.
Thursday
{| class="wikitable" style="width:100%;margin-right:0;text-align:center"
|-
! colspan="2" style="background-color:#C0C0C0;text-align:center"|Network
! style="background-color:#C0C0C0;text-align:center"|8:00 p.m.
! style="background-color:#C0C0C0;text-align:center"|8:30 p.m.
! style="background-color:#C0C0C0;text-align:center"|9:00 p.m.
! style="background-color:#C0C0C0;text-align:center"|9:30 p.m.
! style="background-color:#C0C0C0;text-align:center"|10:00 p.m.
! style="background-color:#C0C0C0;text-align:center"|10:30 p.m.
|-
! rowspan="4"|ABC
! Fall
| colspan="2" rowspan="4"|Father Dowling Mysteries
| colspan="2" rowspan="2"|Gabriel's Fire
| colspan="2" rowspan="4" style="background:#6699CC;"|Primetime Live
|-
! Winter
|-
! Spring
| colspan="2" rowspan="2"|Twin Peaks
|-
! Summer
|-
! rowspan="6"|CBS
! Fall
| rowspan="2"|Top Cops
| rowspan="2" colspan="2"|The Flash
| Doctor Doctor
| rowspan="4" colspan="2"|Knots Landing
|-
! Winter
| Good Sports
|-
! Mid-winter
| rowspan="4" colspan="2"|Top Cops
| colspan="2"|The Flash
|-
! Spring
| colspan="2"|The Antagonists
|-
! Summer
| colspan="2" style="background:#FA8072;"|Over My Dead Body
| colspan="2" style="background:#FA8072;"|Broken Badges
|-
! Late summer
| style="background-color:#C0C0C0;" colspan="2"|The Trials of Rosie O'Neill
| colspan="2"|Golden Years
|-
! rowspan="4"|Fox
! Fall
| rowspan="4" |The Simpsons
| rowspan="3"|Babes
| rowspan="4" colspan="2"|Beverly Hills, 90210
| style="background:#abbfff;" rowspan="4" colspan="2"|
|-
! Winter
|-
! Spring
|-
! Summer
| style="background-color:#C0C0C0;|True Colors
|-
! rowspan="6"|NBC
! Fall
| style="background:#FFFF00" rowspan="6"|The Cosby Show
| style="background:#FFFF00" rowspan="6"|A Different World
| bgcolor="lime" rowspan="6"|Cheers
| style="background:#FF66FF" rowspan="2"|Grand
| colspan="2"|Law & Order
|-
! Mid-fall
| style="background:#FF66FF" rowspan="5" colspan="2"|L.A. Law
|-
! Winter
| Wings
|-
! Spring
| rowspan="2"|Seinfeld
|-
! Summer
|-
! Mid-summer
| Wings
|-
|}
On CBS, Sons and Daughters was supposed to premiere on October 25, 1990, while The Flash is supposed to start at 8:00-9:00 p.m., but the show was shelved.
Friday
{| class="wikitable" style="width:100%;margin-right:0;text-align:center"
|-
! colspan="2" style="background-color:#C0C0C0;text-align:center"|Network
! style="background-color:#C0C0C0;text-align:center"|8:00 p.m.
! style="background-color:#C0C0C0;text-align:center"|8:30 p.m.
! style="background-color:#C0C0C0;text-align:center"|9:00 p.m.
! style="background-color:#C0C0C0;text-align:center"|9:30 p.m.
! style="background-color:#C0C0C0;text-align:center"|10:00 p.m.
! style="background-color:#C0C0C0;text-align:center"|10:30 p.m.
|-
! rowspan="7"|ABC
! Fall
| style="background:#00FFFF;" rowspan="6"|Full House
| style="background:#00FFFF;" rowspan="3"|Family Matters
| rowspan="3"|Perfect Strangers
| rowspan="2"|Going Places
| rowspan="7" colspan="2" style="background-color:#6699CC;"|20/20
|-
! Winter
|-
! Spring
| style="background:#FF66FF;"|Baby Talk
|-
! Mid-spring
| Dinosaurs
| style="background:#00FFFF;"|Family Matters
| Perfect Strangers
|-
! Summer
| style="background:#00FFFF;" rowspan="2"|Family Matters
| rowspan="3"|Perfect Strangers
| Going Places
|-
! Mid-summer
| rowspan="2"|Hi Honey, I'm Home!
|-
! Late summer
| style="background:#00FFFF;"|Family Matters
| style="background:#C0C0C0;"|Growing Pains
|-
! rowspan="9"|CBS
! Fall
| rowspan="2"| Evening Shade
| rowspan="3"|Bagdad Café
| colspan="4" " style="background:#FA8072;"|CBS Friday Movie
|-
! Mid-fall
| colspan="2" rowspan="2"|Over My Dead Body
| colspan="2" rowspan="2"|Dallas
|-
! Late fall
| Uncle Buck
|-
! Winter
| colspan="2" rowspan="3"|Guns of Paradise
| colspan="2" rowspan="2"|Dallas
| colspan="2"|Sons and Daughters
|-
! Spring
| colspan="2" |True Detectives
|-
! Early summer
| colspan="4" rowspan="2" style="background:#FA8072;"|CBS Friday Movie
|-
! Summer
| rowspan="2" style="background:#6699CC;"|Verdict
| rowspan="2" | True Detectives
|-
! Mid-summer
| colspan="2" style="background:#C0C0C0;"|The Flash
| colspan="2" style="background:#FFE082;"|Sweating Bullets
|-
! Late summer
|Fantastic Facts
|Prime Time Pets
| colspan="4" style="background:#FA8072;"|CBS Friday Movie
|-
! rowspan="5"|Fox
! Fall
| rowspan="5" colspan="2"|America's Most Wanted
| colspan="2"|DEA
| style="background:#abbfff;" rowspan="5" colspan="2"|
|-
! Mid-fall
| rowspan="2" colspan="2"|Against the Law
|-
! Winter
|-
! Spring
| rowspan="2" colspan="2"|DEA
|-
! Summer
|-
! rowspan="8"|NBC
! Fall
| colspan="2"|Quantum Leap
| Night Court
| Wings
| colspan="2" rowspan="2"|Midnight Caller
|-
! Winter
| colspan="2" style="background:#FA8072;" rowspan="2"|
| colspan="2" |Dark Shadows
|-
! Spring
| colspan="2" rowspan="3"|Hunter
| colspan="2"|Dark Shadows
|-
! Mid-spring
| colspan="2"|The 100 Lives of Black Jack Savage
| colspan="2" rowspan="3"|Midnight Caller
|-
! Early summer
| colspan="2" style="background:#FA8072;" |
|-
! Summer
| colspan="4" rowspan="2" style="background:#FA8072;"|NBC Friday Night Movie
|-
! Mid-summer
| colspan="2" |Hunter
|-
! Late summer
| style="background:#6699CC;"|Real Life with Jane Pauley
| style="background:#6699CC;"|Expose
| colspan="4" style="background:#FA8072;"|NBC Friday Night Movie
|}
Saturday
{| class="wikitable" style="width:100%;margin-right:0;text-align:center"
|-
! colspan="2" style="background-color:#C0C0C0;text-align:center"|Network
! style="background-color:#C0C0C0;text-align:center"|8:00 p.m.
! style="background-color:#C0C0C0;text-align:center"|8:30 p.m.
! style="background-color:#C0C0C0;text-align:center"|9:00 p.m.
! style="background-color:#C0C0C0;text-align:center"|9:30 p.m.
! style="background-color:#C0C0C0;text-align:center"|10:00 p.m.
! style="background-color:#C0C0C0;text-align:center"|10:30 p.m.
|-
! rowspan="4"|ABC
! Fall
| rowspan="4" colspan="2"|The Young Riders
| colspan="2"|China Beach
| rowspan="2" colspan="2"|Twin Peaks
|-
! Winter
| colspan="2"|Under Cover
|-
! Spring
| rowspan="2" colspan="4" style="background:#FA8072;"|The ABC Saturday Night Movie
|-
! Summer
|-
! rowspan="7"|CBS
! Fall
| rowspan="2"| The Family Man
| rowspan="2"| The Hogan Family
| colspan="2"|E.A.R.T.H. Force
| colspan="2" style="background:#77AACC;"|48 Hours
|-
! Late fall
| colspan="2"|Broken Badges
| colspan="2"|Wiseguy
|-
! Early winter
| You Take the Kids
| rowspan="2"|Lenny
| rowspan="3" colspan="4" style="background:#FA8072;"|CBS Saturday Movie
|-
! Winter
| Uncle Buck
|-
! Spring
| colspan="2"|The Flash
|-
! Summer
| rowspan="2" colspan="4" style="background:#FA8072;"|CBS Saturday Movie
| style="background:#FA8072;"| Doctor Doctor
| style="background:#FA8072;"| Good Sports
|-
! Mid-summer
| colspan="2" style="background:#FA8072;"|
|-
! rowspan="5"|Fox
! Fall
| rowspan="4"|Totally Hidden Video
| rowspan="2"|Haywire
| rowspan="4"|COPS
| American Chronicles
| style="background:#abbfff;" rowspan="5" colspan="2"|
|-
! Winter
| rowspan="3" style="background:#C0C0C0;"|COPS
|-
! Mid-winter
| style="background:#C0C0C0;"| Totally Hidden Video
|-
! Spring
| Yearbook
|-
! Summer
| COPS
| style="background:#C0C0C0;"|COPS
| Totally Hidden Video
| style="background:#C0C0C0;"|Babes
|-
! rowspan="6"|NBC
! Fall
| Parenthood
| Working It Out
| style="background:#00FFFF;" rowspan="5"|The Golden Girls
| style="background:#FFFF00;" rowspan="5"|Empty Nest
| rowspan="2"|Carol & Company
|American Dreamer
|-
! Winter
| rowspan="4"|Amen
|The Fanelli Boys
|Dear John
|-
! Spring
| Down Home
| colspan="2"|Carol & Company
|-
! Summer
| style="background:#FA8072;" | American Dreamer
| colspan="2"|Sisters
|-
! Mid-summer
| Down Home
|Dear John
|Carol & Company
|-
! Late summer
| style="background:#00FFFF;" |The Golden Girls
| style="background:#C0C0C0;" |The Golden Girls
| style="background:#FFFF00;" |Empty Nest
|Dear John
| colspan="2"|Sisters
|}
By network
ABC
;Returning series
- 20/20
- The ABC Monday Night Movie
- The ABC Saturday Night Movie
- The ABC Sunday Night Movie
- America's Funniest Home Videos
- Anything but Love
- China Beach
- Coach
- Doogie Howser, M.D.
- Equal Justice
- Family Matters
- Father Dowling Mysteries
- Full House
- Growing Pains
- Head of the Class
- Life Goes On
- MacGyver
- Monday Night Football
- Perfect Strangers
- Primetime Live
- Roseanne
- Thirtysomething
- Twin Peaks
- Who's the Boss?
- The Wonder Years
- The Young Riders
;New series
- America's Funniest People *
- Baby Talk *
- Cop Rock
- Davis Rules
- Dinosaurs *
- Eddie Dodd *
- Gabriel's Fire
- Going Places
- Hi Honey, I'm Home! *
- The Man in the Family *
- Married People
- My Life and Times *
- Stat *
- Under Cover *
Not returning from 1989–90:
- The ABC Mystery Movie
- Brewster Place
- Capital News
- Chicken Soup
- Elvis
- Free Spirit
- H.E.L.P.
- Homeroom
- Just the Ten of Us
- Living Dolls
- The Marshall Chronicles
- Mission: Impossible
- Mr. Belvedere
- Monopoly
- Sunset Beat
- Super Jeopardy!
- Tim Conway's Funny America
CBS
;Returning series
- 48 Hours
- 60 Minutes
- Bagdad Café
- CBS Sunday Movie
- Dallas
- Designing Women
- Doctor Doctor
- Guns of Paradise (formerly known as Paradise)
- The Hogan Family (moved from NBC)
- Jake and the Fatman
- Knots Landing
- Major Dad
- Murder, She Wrote
- Murphy Brown
- Northern Exposure
- Rescue 911
- Wiseguy
;New series
- The Antagonists *
- Broken Badges *
- E.A.R.T.H. Force
- Evening Shade
- The Family Man
- Fantastic Facts *
- The Flash
- Golden Years
- Good Sports *
- Lenny
- Morton & Hayes *
- Over My Dead Body
- Sons and Daughters *
- Sunday Dinner *
- The Trials of Rosie O'Neill
- True Detectives *
- Uncle Buck
- Verdict *
- WIOU
- You Take the Kids *
Not returning from 1989–90:
- Beauty and the Beast
- The Bradys
- City
- Falcon Crest
- The Famous Teddy Z
- Grand Slam
- His & Hers
- Island Son
- Max Monroe: Loose Cannon
- Newhart
- Normal Life
- A Peaceable Kingdom
- The People Next Door
- Prime Time Pets
- Room for Romance
- Saturday Night with Connie Chung
- Small Talk
- Snoops
- Sugar and Spice
- Sydney
- Top of the Hill
- Tour of Duty
- Wolf
Fox
;Returning series
- America's Most Wanted
- Comic Strip Live
- Cops
- In Living Color
- Married... with Children
- The Simpsons
- Totally Hidden Video
;New series
- Against the Law
- American Chronicles
- Babes
- Beverly Hills, 90210
- DEA
- FOX Night At The Movies
- Get a Life
- Good Grief
- Haywire
- Parker Lewis Can't Lose
- The Sunday Comics *
- Top of the Heap *
- True Colors
- Yearbook
Not returning from 1989–90:
- 21 Jump Street (moved to syndication)
- Alien Nation
- Beyond Tomorrow
- Booker
- It's Garry Shandling's Show
- Glory Days
- Molloy
- Open House
- The Outsiders
- The Reporters
- The Tracey Ullman Show
NBC
;Returning series
- Amen
- Cheers
- The Cosby Show
- Dear John
- A Different World
- Down Home
- Empty Nest
- The Golden Girls
- Grand
- Hunter
- In the Heat of the Night
- L.A. Law
- Matlock
- Midnight Caller
- NBC Sunday Night Movie
- NBC Monday Night at the Movies
- Night Court
- Quantum Leap
- Real Life with Jane Pauley
- Seinfeld
- Shannon's Deal
- Unsolved Mysteries
- Wings
;New series
- The 100 Lives of Black Jack Savage *
- American Dreamer
- Blossom *
- Dark Shadows *
- Expose *
- The Fanelli Boys
- Ferris Bueller
- The Fresh Prince of Bel-Air
- Hull High
- Lifestories
- Law & Order
- Parenthood
- Sisters *
- Sunday Best *
- Working It Out
Not returning from 1989–90:
- 13 East
- 227
- ALF
- Ann Jillian
- Baywatch (moved to syndication in September 1991)
- Brand New Life
- Carol and Company
- A Family for Joe
- FM
- Hardball
- The Hogan Family (moved to CBS)
- The Magical World of Disney (moved to ABC)
- Mancuso, F.B.I.
- My Two Dads
- Nasty Boys
- The Nutt House
- Singer & Sons
- Sister Kate
- True Blue
- Working Girl
Note: The * indicates that the program was introduced in midseason.
