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The following lists events that happened during 1901 in South Africa.
Incumbents
Cape Colony
- Governor of the Cape of Good Hope and High Commissioner for Southern Africa:Alfred Milner then Walter Hely-Hutchinson (governor from 6 March but not high commissioner).
- Prime Minister of the Cape of Good Hope: John Gordon Sprigg.
Natal
- Governor of the Colony of Natal: Charles Bullen Hugh Mitchell (until 6 May), Henry Edward McCallum (starting 6 May).
- Prime Minister of the Colony of Natal: Albert Henry Hime.
Orange Free State
- State President of the Orange Free State: Martinus Theunis Steyn.
- Administrator of British-occupied Orange River Colony and UK High Commissioner for Southern Africa: Alfred Milner, 1st Viscount Milner.
South African Republic
- State President of the South African Republic: Paul Kruger (in exile); Schalk Willem Burger (acting).
- Administrator of British-occupied Transvaal and UK High Commissioner for Southern Africa: Alfred Milner, 1st Viscount Milner.
Events
;January
- 9 – Herbert Kitchener reports that Christiaan de Wet has shot a British peace envoy and flogged two more who had gone to his commando to ask the Burghers to halt fighting.
- 15 – HMS Sybille, a 3,400-ton , strikes a reef about south of Lamberts Bay.
- 31 – General Jan Smuts and his commandos capture Modderfontein.
;February
- 1 – Bubonic plague breaks out in Cape Town.
- 26 – The Middelburg peace conference fails as Boers continue to demand autonomy.
;May
- 31 – Officially unrecognized Zulu king Dinuzulu kaCetshwayo refuses British instructions to take up arms against the Boers.
;June
- 18 – Emily Hobhouse reports on the high mortality and cruel conditions in the Second Boer War concentration camps
- 25 – Boer armies invaded the Cape Colony and attacked the British settlement of Richmond for a day, then retreated as British forces approached.
;July
- 2–6 – Nine Boer prisoners-of-war are murdered by Australian members of the Bushveldt Carbineers in the Spelonken area near Louis Trichardt.
- 16 – The Fawcett Commission is established to look at living conditions of women and children, including water supply, sanitation, medical care and the mortality and birth rates in the concentration camps.
;August
- 4 – Lieutenant-general Paul Methuen destroys the village of Schweizer-Reneke under the British scorched earth policy.
- 20 – General Koos de la Rey's 84-year-old mother is sent to a concentration camp at Klerksdorp.
;September
- 17 – Commandant-General Louis Botha and General Cecil "Cherry" Cheere Emmett join forces to invade Natal.
;October
- Mahatma Gandhi embarks at Durban for Mauritius en route to Bombay.
;November
- 1 – Standard Bank opens its second branch in Johannesburg on Eloff Street.
- 9 – The electric tramline in Cape Town is extended from Sea Point to Camps Bay.
- 18 – Boer commandos invade the Cape Colony and come to within 50 miles of Cape Town.
;December
- 22 – On Peace Sunday Charles Frederic Aked (1864–1941), a Baptist minister in Liverpool, says: "Great Britain cannot win the battles without resorting to the last despicable cowardice of the most loathsome cur on earth; the act of striking a brave man's heart through his wife's honour and his child's life. The cowardly war has been conducted by methods of barbarism... the concentration camps have been Murder Camps." A crowd follows him home and breaks the windows of his house.
- 27 July – Natal – Mtwalume to North Shepstone, .
Locomotives
;Cape
- Six new Cape gauge locomotive types enter service on the Cape Government Railways (CGR):
- Six 4-4-0 3rd Class Wynberg Tender locomotives in suburban service in Cape Town.
- Eight redesigned American-built 6th Class 4-6-0 steam locomotives. In 1912 they would be designated South African Class 6G 4-6-0| on the South African Railways (SAR).
- The first of sixteen 8th Class 2-8-0| Consolidation type locomotives. In 1912 they would be designated Class 8X on the SAR.
- The Namaqua Copper Company acquires its first locomotive, a 0-4-2 saddle-tank shunting engine named Pioneer.
;Natal
- The Natal Government Railways (NGR) rebuilds one of its Class G tank locomotives to a Class H Pacific wheel arrangement. In 1912 it would be designated Class C1 on the SAR.
- The Zululand Railway Company, contracted for the construction of the line from Verulam to Tugela River, acquires one 2-6-2 tank locomotive.
