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The following lists events that happened during 1880 in South Africa.
Incumbents
- Governor of the Cape of Good Hope and High Commissioner for Southern Africa: John Gordon Sprigg.
- Lieutenant-governor of the Colony of Natal: Henry Ernest Gascoyne Bulwer.
- State President of the Orange Free State: Jan Brand.
- State President of the South African Republic: Triumviate of Paul Kruger, Marthinus Wessel Pretorius and Piet Joubert.
- Lieutenant-Governor of Griqualand West: James Rose Innes (until 15 October).
- Prime Minister of the Cape of Good Hope: John Gordon Sprigg.
- Monarch - Queen Alexandrina Victoria
Events
;March
- 20 March – £50,000 worth of diamonds are reported stolen from Cape Town's post office.
;April
- Paul Kruger and Joubert travel to the Cape to campaign against the federation. Their mission succeeds, but Gladstone refuses self-rule.
- 23 April – Eugénie de Montijo, wife of Emperor Napoleon III of France, arrives in Durban to visit the grave of her son, Napoléon Eugène, Prince Imperial, who was killed in Zululand during the Anglo-Zulu War in 1879.
;June
- 15 June – The Natal South Coast railway line from Durban is opened to traffic to Isipingo.
;August
- British Governor Bartle Frere is recalled to London to face charges of misconduct.
;September
- Cape Prime Minister Gordon Sprigg's attempt at disarming the Basotho ignites the Basuto Gun War.
;October
- 18 October – Griqualand West is annexed to the Cape Colony.
;December
- The Volksraad meet at Paardekraal, as Kruger, Joubert, and Pretorius form the new republic's government. Kruger-based in Heidelberg, armed forces take positions on the Natal border and around the British garrison in the Transvaal. Kruger seeks negotiations, knowing that the British forces are stronger.
- First keeper of the Colonial Archives of the Cape Colony is appointed.
- 5 February – Cape Western – Fraserburg Road to Beaufort West, .
- 2 March – Cape Midland – Middleton to Cookhouse, .
Locomotives
- The Cape Government Railways places the first nine of eighteen 4th Class tank-and-tender locomotives in mainline service on its Midland System working out of Port Elizabeth and Eastern System working out of East London.
- The Natal Government Railways places a Class K saddle-tank locomotive in service.
