<!-- "none" is preferred when the title is sufficiently descriptive; see WP:SDNONE -->
The year 1653 in science and technology involved some significant events.
Biology
- Jan van Kessel paints a series of pictures of insects and fruit.
Mathematics
- Blaise Pascal publishes his Traité du triangle arithmétique in which he describes a convenient tabular presentation for binomial coefficients, now called Pascal's triangle.
Physics
- Blaise Pascal publishes his Treatise on the Equilibrium of Liquids in which he explains his law of pressure.
Births
- January 16 – Johann Conrad Brunner, Swiss anatomist (died 1727)
- March 24 – Joseph Sauveur, French mathematician and acoustician (died 1716)
Deaths
- Jan Stampioen, Dutch mathematician (born 1610) (gunpowder explosion)