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The following events in the fields of science and technology occurred in the year 1577.
Astronomy
- The Constantinople Observatory of Taqi ad-Din is completed.
- The Great Comet of 1577 is seen. Tycho Brahe is able to discover from his observations that comets and similar objects travel above the Earth's atmosphere.
Mechanics
- Guidobaldo del Monte, Marchese del Monte, publishes Mechanicorum Liber in Pisa.
Medicine
- Publication of John Frampton's , an English translation from Nicolás Monardes' Historia medicinal de las cosas que se traen de nuestras Indias Occidentales (1565).
Technology
- English race-built galleon Revenge launched at the Royal Dockyard, Deptford, by Master Shipwright Mathew Baker.
Births
- October 3 – Fortunio Liceti, Italian Aristotelian scientific polymath (died 1657)
Deaths
- Pietro Andrea Mattioli, Italian physician and botanist (born 1501)
- Adam von Bodenstein, Swiss alchemist and physician (born 1528)