125th Street may refer:
Art, entertainment, and media
- 125th Street (musical), a stage show which opened in September 2002 at London's Shaftesbury Theatre
Roads, bridges, and train stations
- 125th Street (Manhattan), a street in Manhattan, New York City
- Florida State Road 822 in Miami-Dade County, locally known as 125th Street
- Harlem–125th Street station, a commuter railroad station in Manhattan
- Stations of the New York City subway and its predecessors:
- 125th Street station (IND Eighth Avenue Line), at St. Nicholas Avenue; serving the trains
- 125th Street station (IRT Broadway–Seventh Avenue Line), at Broadway; serving the train
- 125th Street station (IRT Lenox Avenue Line), at Malcolm X Boulevard; serving the trains
- 125th Street station (IRT Lexington Avenue Line), at Lexington Avenue; serving the trains
- 125th Street station (IRT Ninth Avenue Line), at Eighth Avenue (demolished)
- 125th Street station (IRT Second Avenue Line), at Second Avenue (demolished)
- 125th Street station (IRT Third Avenue Line), at Third Avenue (demolished)